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Ouabain --- Hypertension --- Muscles --- Potassium --- Sodium-Potassium-Exchanging ATPase --- metabolism --- metabolism --- metabolism --- pharmacology --- metabolism

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There is unequivocal experimental, epidemiological, and clinical evidence demonstrating a correlation between diet and increased risk of cardiovascular disease (CVD). While nutritionally-poor diets can have a significant negative impact on cardiovascular health, dietary interventions with specific nutrients and/or functional foods are considered cost-effective and efficient components of prevention strategies. It has been estimated that nutritional factors may be responsible for approximately 40% of all CVD. Indeed, in one of the seminal studies conducted on modifiable risk factors and heart health (the INTERHEART study), >90% of all myocardial infarctions were attributed to preventable environmental factors with nutrition identified as one of the important determinants of CVD. There is an increasing public interest in and scientific investigation into establishing dietary approaches that can be undertaken for the prevention and treatment of CVD. This Special Issue provides an insight into the influential role of nutrition and dietary habits on cardiovascular health and disease, as well as their mechanisms of therapeutic and preventive action.

Research & information: general --- Biology, life sciences --- Food & society --- magnesium deficiency --- arterial hypertension --- vascular tone --- arterial stiffness --- vascular remodeling --- insulin resistance --- magnesium supplementation --- dietary magnesium intake --- Zeb2 --- cardiac fibroblast --- activated myofibroblast --- cardiac fibrosis --- fibroblast contractility --- fish oil --- omega-3 fatty acids --- eicosapentaenoic acid (EPA) --- docosahexaenoic acid (DHA) --- cardiovascular disease --- irisin --- pediatric --- children --- nutrition --- diet --- body composition --- metabolic syndrome --- obesity, neonates --- Mediterranean diet --- inflammation --- nutrients --- polyphenols --- MUFA --- PUFA --- bioactive compounds --- phytosterols --- dietary pattern --- Aronia melanocarpa --- standardized extract --- dietary strategies --- supplementation --- cocaine --- cardiovascular health --- heart disease --- acute effects --- chronic effects --- marinobufagenin --- ouabain --- salt --- hypertension --- fibrosis --- Panax quinquefolius --- ginseng berry --- myocardial infarction --- phenolic compounds --- vascular aging --- vascular calcification --- arteriosclerosis --- Klotho --- chronic kidney disease (CKD), cancer --- diabetes --- heart failure --- micronutrients --- iron --- vitamins --- trace elements --- vitamin D --- seasonal variation --- lifestyle --- cytokines --- lipids --- mechanisms --- immunoregulatory --- eicosapentaenoic acid --- docosahexaenoic acid --- omega-3 polyunsaturated fatty acids --- coronary heart disease --- stretching --- TGF-β1 --- n/a

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• Reference Manager
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There is unequivocal experimental, epidemiological, and clinical evidence demonstrating a correlation between diet and increased risk of cardiovascular disease (CVD). While nutritionally-poor diets can have a significant negative impact on cardiovascular health, dietary interventions with specific nutrients and/or functional foods are considered cost-effective and efficient components of prevention strategies. It has been estimated that nutritional factors may be responsible for approximately 40% of all CVD. Indeed, in one of the seminal studies conducted on modifiable risk factors and heart health (the INTERHEART study), >90% of all myocardial infarctions were attributed to preventable environmental factors with nutrition identified as one of the important determinants of CVD. There is an increasing public interest in and scientific investigation into establishing dietary approaches that can be undertaken for the prevention and treatment of CVD. This Special Issue provides an insight into the influential role of nutrition and dietary habits on cardiovascular health and disease, as well as their mechanisms of therapeutic and preventive action.

Research & information: general --- Biology, life sciences --- Food & society --- magnesium deficiency --- arterial hypertension --- vascular tone --- arterial stiffness --- vascular remodeling --- insulin resistance --- magnesium supplementation --- dietary magnesium intake --- Zeb2 --- cardiac fibroblast --- activated myofibroblast --- cardiac fibrosis --- fibroblast contractility --- fish oil --- omega-3 fatty acids --- eicosapentaenoic acid (EPA) --- docosahexaenoic acid (DHA) --- cardiovascular disease --- irisin --- pediatric --- children --- nutrition --- diet --- body composition --- metabolic syndrome --- obesity, neonates --- Mediterranean diet --- inflammation --- nutrients --- polyphenols --- MUFA --- PUFA --- bioactive compounds --- phytosterols --- dietary pattern --- Aronia melanocarpa --- standardized extract --- dietary strategies --- supplementation --- cocaine --- cardiovascular health --- heart disease --- acute effects --- chronic effects --- marinobufagenin --- ouabain --- salt --- hypertension --- fibrosis --- Panax quinquefolius --- ginseng berry --- myocardial infarction --- phenolic compounds --- vascular aging --- vascular calcification --- arteriosclerosis --- Klotho --- chronic kidney disease (CKD), cancer --- diabetes --- heart failure --- micronutrients --- iron --- vitamins --- trace elements --- vitamin D --- seasonal variation --- lifestyle --- cytokines --- lipids --- mechanisms --- immunoregulatory --- eicosapentaenoic acid --- docosahexaenoic acid --- omega-3 polyunsaturated fatty acids --- coronary heart disease --- stretching --- TGF-β1 --- n/a

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Arterial hypertension affects about 1 billion people worldwide and it is the strongest modifiable risk factor for cardiovascular disease and related disability. Since the initial discovery of rare monogenic disorders with large effects, the role of genomics has evolved into large genome-wide association studies detecting common variants with a modest effect size. Similarly, pharmacogenomics has emerged as a new tool for understanding variability in drug response, to maximize efficacy and reduce toxicity. This book presents the most recent advances in the field of genetics and genomics of arterial hypertension and their potential impact on clinical management. The book is a useful tool for clinicians but also to the research community and those who want to be updated in the field.

atrial natriuretic peptide --- T2238C variant --- endothelial dysfunction --- smooth muscle cells contraction --- platelet aggregation --- epigenetics --- cardiovascular diseases --- renin --- low-renin --- hypertension --- mineralocorticoid receptor --- genetics --- aldosterone --- essential hypertension --- blood pressure --- genome-wide association studies --- exome microarray --- next-generation sequencing --- rare variants --- rare-variants association testing --- burden test --- sequence kernel association test --- hypokalemia --- low renin hypertension --- monogenic hypertension --- Liddle syndrome --- SCNN1A --- SCNN1B --- SCNN1G --- non-coding RNA --- micro RNA --- primary aldosteronism --- aldosterone-producing adenoma --- transcriptome profiing --- DNA methylation --- histone modifications --- vascular smooth muscle cells --- endothelial cells --- Kruppel-like factor 15 --- left ventricular hypertrophy --- cardiac hypertrophy --- heart failure --- genetics of left ventricular hypertrophy --- fibromuscular dysplasia --- non atherosclerotic vascular stenosis --- PHACTR1 --- genetic association --- cervical artery dissection --- spontaneous coronary arteries dissection --- CRY1 --- CRY2 --- HSD3B1 --- HSD3B2 --- cardio-tonic steroids --- endogenous ouabain --- adducin --- renal damage --- African American --- ARMC5 --- GRK4 --- CACNA1D --- endocrine hypertension

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The health benefits of food, plants, fruits, and seaweeds stem from the biological activities of their constituents—namely, secondary metabolites. The study of secondary metabolites and their potential to treat and/or prevent a number of diseases has become a research topic of growing interest for biologists, pharmacists, and chemists. Notably, in order to propose a compound as a potential new drug with pharmacological effects, the chemical structure of this compound and its biological activity against a given target must be well established. The Special Issue, “Isolation and Identification of Bioactive Secondary Metabolites”, considers species beyond their nutritional value and identifies instances of wider and more efficient use, thereby contributing to a more sustainable management of natural resources. The fifteen articles published in this Special Issue reflect the latest research trends, and consider the isolation, identification, and assessment of the beneficial effects of secondary metabolites from both edible and inedible species. Thus, these contributions collectively demonstrate that these compounds, and their plants of origin, should be valued beyond their nutritional benefits.

Medicine --- Pharmacology --- coumarins --- Lycium --- metabolomic --- HPLC-MS --- orbitrap --- secondary metabolites --- endemic plants --- olive leaves --- supercritical fluid extraction --- antioxidants --- hyperuricemia --- plant-based functional food --- xanthine oxidase --- adenosine deaminase --- uric acid transporter --- bioactive compound --- Piper pseudoarboreum --- bioassay-guided fractionation --- leishmanicidal activity --- alkamides --- (E)-piplartine --- Wedelia chinensis --- organic farming --- phytotoxic substances --- vanillic acid --- gallic acid --- Origanum subspecies --- morphological traits --- glandular trichomes --- essential oil composition --- rosmarinic acid --- sensory evaluation --- colored potato tubers --- total phenols --- anthocyanins --- saccharides --- nutrition --- microelements --- plants --- fungi --- food supplements --- cardiovascular diseases --- neurodegenerative diseases --- Alzheimer’s disease --- metabolic syndrome --- apocarotenoid --- caffeic acid derivative --- flavonoid --- Lactuca sativa --- lignan --- megastigmane --- sesquiterpene lactone --- 1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid --- black chokeberry --- anthocyanin --- simulated moving bed --- antioxidant activity --- neuroprotection --- Artemisia --- clinical trials --- health effects --- adverse effects --- anticancer --- antiparasitic --- artemisinin --- santonin --- achillin --- tehranolide --- Aglaomorpha quercifolia --- GC-MS profile --- rhizome --- leaves --- n-hexane extract --- fatty acids --- terpenoids --- linolenic acid --- hop-16-ene --- cardiac glycosides --- secondary plant metabolites --- natural product isolation --- hyrcanoside --- deglucohyrcanoside --- ouabain --- cymarin --- digitoxin --- anticancer activity --- Na+/K+-ATPase inhibitors --- corn salad --- leafy vegetables --- phytochemicals --- liquid chromatography --- mass spectrometry --- celastrol --- Celastraceae --- antimicrobial activity --- mechanism of action --- Bacillus subtilis --- n/a --- Alzheimer's disease